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Investment Strategy: Part VIII For analysts building pharmaceutical company models incorporating IRA impact, the key variables are: the Medicare share of revenue for each major asset (drugs with low Medicare penetration are minimally affected by MFP), the expected year of eligibility for MFP negotiation relative to the patent expiry date (if negotiation eligibility arrives after patent expiry, the IRA provision is irrelevant for that asset), and the biologic/small-molecule classification of each major pipeline asset

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